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Nature genetics · 2011

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

СтатьяМетаанализПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Naj Adam C, Jun Gyungah, Beecham Gary W, Wang Li-San, Vardarajan Badri Narayan, Buros Jacqueline, Gallins Paul J, Buxbaum Joseph D, Jarvik Gail P, Crane Paul K, Larson Eric B, Bird Thomas D, Boeve Bradley F, Graff-Radford Neill R, De Jager Philip L, Evans Denis, Schneider Julie A, Carrasquillo Minerva M, Ertekin-Taner Nilufer, Younkin Steven G, Cruchaga Carlos, Kauwe John S K, Nowotny Petra, Kramer Patricia, Hardy John, Huentelman Matthew J, Myers Amanda J, Barmada Michael M, Demirci F Yesim, Baldwin Clinton T, Green Robert C, Rogaeva Ekaterina, St George-Hyslop Peter, Arnold Steven E, Barber Robert, Beach Thomas, Bigio Eileen H, Bowen James D, Boxer Adam, Burke James R, Cairns Nigel J, Carlson Chris S, Carney Regina M, Carroll Steven L, Chui Helena C, Clark David G, Corneveaux Jason, Cotman Carl W, Cummings Jeffrey L, DeCarli Charles, DeKosky Steven T, Diaz-Arrastia Ramon, Dick Malcolm, Dickson Dennis W, Ellis William G, Faber Kelley M, Fallon Kenneth B, Farlow Martin R, Ferris Steven, Frosch Matthew P, Galasko Douglas R, Ganguli Mary, Gearing Marla, Geschwind Daniel H, Ghetti Bernardino, Gilbert John R, Gilman Sid, Giordani Bruno, Glass Jonathan D, Growdon John H, Hamilton Ronald L, Harrell Lindy E, Head Elizabeth, Honig Lawrence S, Hulette Christine M, Hyman Bradley T, Jicha Gregory A, Jin Lee-Way, Johnson Nancy, Karlawish Jason, Karydas Anna, Kaye Jeffrey A, Kim Ronald, Koo Edward H, Kowall Neil W, Lah James J, Levey Allan I, Lieberman Andrew P, Lopez Oscar L, Mack Wendy J, Marson Daniel C, Martiniuk Frank, Mash Deborah C, Masliah Eliezer, McCormick Wayne C, McCurry Susan M, McDavid Andrew N, McKee Ann C, Mesulam Marsel, Miller Bruce L, Miller Carol A, Miller Joshua W, Parisi Joseph E, Perl Daniel P, Peskind Elaine, Petersen Ronald C, Poon Wayne W, Quinn Joseph F, Rajbhandary Ruchita A, Raskind Murray, Reisberg Barry, Ringman John M, Roberson Erik D, Rosenberg Roger N, Sano Mary, Schneider Lon S, Seeley William, Shelanski Michael L, Slifer Michael A, Smith Charles D, Sonnen Joshua A, Spina Salvatore, Stern Robert A, Tanzi Rudolph E, Trojanowski John Q, Troncoso Juan C, Van Deerlin Vivianna M, Vinters Harry V, Vonsattel Jean Paul, Weintraub Sandra, Welsh-Bohmer Kathleen A, Williamson Jennifer, Woltjer Randall L, Cantwell Laura B, Dombroski Beth A, Beekly Duane, Lunetta Kathryn L, Martin Eden R, Kamboh M Ilyas, Saykin Andrew J, Reiman Eric M, Bennett David A, Morris John C, Montine Thomas J, Goate Alison M, Blacker Deborah, Tsuang Debby W, Hakonarson Hakon, Kukull Walter A, Foroud Tatiana M, Haines Jonathan L, Mayeux Richard, Pericak-Vance Margaret A, Farrer Lindsay A, Schellenberg Gerard D

Аннотация

The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint analysis and meta-analysis approaches were used. We obtained genome-wide significant results at MS4A4A (rs4938933; stages 1 and 2, meta-analysis P (P(M)) = 1.7 × 10(-9), joint analysis P (P(J)) = 1.7 × 10(-9); stages 1, 2 and 3, P(M) = 8.2 × 10(-12)), CD2AP (rs9349407; stages 1, 2 and 3, P(M) = 8.6 × 10(-9)), EPHA1 (rs11767557; stages 1, 2 and 3, P(M) = 6.0 × 10(-10)) and CD33 (rs3865444; stages 1, 2 and 3, P(M) = 1.6 × 10(-9)). We also replicated previous associations at CR1 (rs6701713; P(M) = 4.6 × 10(-10), P(J) = 5.2 × 10(-11)), CLU (rs1532278; P(M) = 8.3 × 10(-8), P(J) = 1.9 × 10(-8)), BIN1 (rs7561528; P(M) = 4.0 × 10(-14), P(J) = 5.2 × 10(-14)) and PICALM (rs561655; P(M) = 7.0 × 10(-11), P(J) = 1.0 × 10(-10)), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты