Archives of neurology · 2010
Association of higher levels of high-density lipoprotein cholesterol in elderly individuals and lower risk of late-onset Alzheimer disease.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Reitz Christiane, Tang Ming-Xin, Schupf Nicole, Manly Jennifer J, Mayeux Richard, Luchsinger José A
Аннотация
OBJECTIVE: To reexamine the association of lipid levels with Alzheimer disease (AD) using Cox proportional hazards models.
DESIGN: Prospective cohort study.
SETTING: Northern Manhattan, New York.
PARTICIPANTS: One thousand one hundred thirty elderly individuals free of cognitive impairment at baseline.
MAIN OUTCOME MEASURE: High-density lipoprotein cholesterol (HDL-C) levels.
RESULTS: Higher levels of HDL-C (>55 mg/dL) were associated with a decreased risk of both probable and possible AD and probable AD compared with lower HDL-C levels (hazard ratio, 0.4; 95% confidence interval, 0.2-0.9; P = .03 and hazard ratio, 0.4; 95% confidence interval, 0.2-0.9; P = .03). In addition, higher levels of total and non-HDL-C were associated with a decreased risk of AD in analyses adjusting for age, sex, education, ethnic group, and APOE e4 genotype.
CONCLUSION: High HDL-C levels in elderly individuals may be associated with a decreased risk of AD.
DESIGN: Prospective cohort study.
SETTING: Northern Manhattan, New York.
PARTICIPANTS: One thousand one hundred thirty elderly individuals free of cognitive impairment at baseline.
MAIN OUTCOME MEASURE: High-density lipoprotein cholesterol (HDL-C) levels.
RESULTS: Higher levels of HDL-C (>55 mg/dL) were associated with a decreased risk of both probable and possible AD and probable AD compared with lower HDL-C levels (hazard ratio, 0.4; 95% confidence interval, 0.2-0.9; P = .03 and hazard ratio, 0.4; 95% confidence interval, 0.2-0.9; P = .03). In addition, higher levels of total and non-HDL-C were associated with a decreased risk of AD in analyses adjusting for age, sex, education, ethnic group, and APOE e4 genotype.
CONCLUSION: High HDL-C levels in elderly individuals may be associated with a decreased risk of AD.