Association of β-fibrinogen gene polymorphism and plasma fibrinogen and allergic purpura nephritis.

OBJECTIVE

To investigate the association of β-fibrinogen gene polymorphism with plasma fibrinogen and allergic purpura nephritis.

METHODS

We designed a case-control study (334 case and 300 control) to genotype the β-fibrinogen gene -455G/A polymorphism. The genotype and allele frequencies between the case and control group were compared. And we also compared the Fg concentration between different genotype.

RESULTS

In the case group, there were 143 cases of GA type, accounting for 42.8%; there were 168 cases of GG type, accounting for 50.3%; there were 23 cases of AA type, accounting for 6.9%. While in the control group, GG type was the most common. There were 228 cases of GG type, accounting for 76%; there were 66 cases of GA type, accounting for 22%; there was 6 case of AA type, accounting for 2%. The frequency of Fgβ-455G/A genotype between the two groups showed statistical significance (P<0.05). The levels of plasma Fg in the two groups showed statistical significance (P<0.01). In HSPN group Fgβ GA and AA-type the concentration of Fg [(4.2 ± 0.5) g/L], compared with the GG genotype [(3.1 ± 0.4) g/L], was significantly increased with statistical significance (P<0.01).

CONCLUSION

The Fgβ-455G/A polymorphism was associated with the risk for HSPN and Fg concentration.