International endodontic journal · 2025
Pulp Response to Materials Used in the Management of Deep Carious Lesions Without Pulp Exposure: A Systematic Review and Network Meta-Analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод в очереди
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BaHammam Fahad, Aldakhil Sultan, Akhil Jamal, Whitworth John
Аннотация
BACKGROUND: Placing a pulp-capping material over the remaining dentine is integral to managing deep carious lesions in permanent teeth without pulp exposure. However, current guidelines do not favour any specific pulp-capping material, and there is no direct clinical evidence that pulp-capping materials maintain pulp vitality better than placing the restoration directly on dentine.
OBJECTIVES: To compare the effectiveness of various biomaterials, including pulp-capping materials and restorative materials applied directly over the remaining dentine, against one another in preserving pulp health in permanent teeth with deep carious lesions without pulp exposure.
METHODS: On June 9, 2024, MEDLINE, Embase, Scopus, and Web of Science were searched, supplemented by a screening of clinical trial registries, grey literature, and reference lists. Randomised controlled trials (RCTs) evaluating the effectiveness of indirect pulp capping in permanent teeth affected by deep carious lesions without pulp exposure were included. Risk of bias was assessed using the revised Cochrane risk-of-bias tool for randomised trials (RoB 2). Network meta-analyses and meta-regression were performed using a Bayesian approach and a random-effects model for the primary outcome (loss of pulp vitality), followed by an assessment of confidence in the evidence using the CINeMA framework.
RESULTS: Sixteen RCTs (19 reports; 1039 participants; 1093 teeth; seven biomaterials) were included. Most comparisons involving the dentine bonding agent (DBA; control) were supported by low-confidence evidence and lacked statistical significance; however, they always resulted in RRs favouring the pulp-capping materials. Notably, moderate-confidence evidence indicated that during the second follow-up year Biodentine (RR = 0.00; 95% CI: 0.00-0.53) and glass ionomer cement (GIC) (RR = 0.30; 95% CI: 0.00-0.99) outperformed the DBA. Moderate-confidence evidence also demonstrated that during the first follow-up year mineral trioxide aggregate (MTA) (RR = 0.30; 95% CI: 0.09-0.84) outperformed calcium hydroxide cement. Meta-regression found that neither study-level demographic covariates nor clinical-technique covariates were significantly associated with pulp-vitality outcome.
CONCLUSIONS: While most findings in this review were of low confidence, the evidence nevertheless supports the use of pulp-capping materials in permanent teeth with deep carious lesions. Among these materials, Biodentine, MTA, and GIC have the strongest supporting evidence for preserving pulp vitality.
TRIAL REGISTRATION: PROSPERO number: CRD42024507641.
OBJECTIVES: To compare the effectiveness of various biomaterials, including pulp-capping materials and restorative materials applied directly over the remaining dentine, against one another in preserving pulp health in permanent teeth with deep carious lesions without pulp exposure.
METHODS: On June 9, 2024, MEDLINE, Embase, Scopus, and Web of Science were searched, supplemented by a screening of clinical trial registries, grey literature, and reference lists. Randomised controlled trials (RCTs) evaluating the effectiveness of indirect pulp capping in permanent teeth affected by deep carious lesions without pulp exposure were included. Risk of bias was assessed using the revised Cochrane risk-of-bias tool for randomised trials (RoB 2). Network meta-analyses and meta-regression were performed using a Bayesian approach and a random-effects model for the primary outcome (loss of pulp vitality), followed by an assessment of confidence in the evidence using the CINeMA framework.
RESULTS: Sixteen RCTs (19 reports; 1039 participants; 1093 teeth; seven biomaterials) were included. Most comparisons involving the dentine bonding agent (DBA; control) were supported by low-confidence evidence and lacked statistical significance; however, they always resulted in RRs favouring the pulp-capping materials. Notably, moderate-confidence evidence indicated that during the second follow-up year Biodentine (RR = 0.00; 95% CI: 0.00-0.53) and glass ionomer cement (GIC) (RR = 0.30; 95% CI: 0.00-0.99) outperformed the DBA. Moderate-confidence evidence also demonstrated that during the first follow-up year mineral trioxide aggregate (MTA) (RR = 0.30; 95% CI: 0.09-0.84) outperformed calcium hydroxide cement. Meta-regression found that neither study-level demographic covariates nor clinical-technique covariates were significantly associated with pulp-vitality outcome.
CONCLUSIONS: While most findings in this review were of low confidence, the evidence nevertheless supports the use of pulp-capping materials in permanent teeth with deep carious lesions. Among these materials, Biodentine, MTA, and GIC have the strongest supporting evidence for preserving pulp vitality.
TRIAL REGISTRATION: PROSPERO number: CRD42024507641.