The American journal of medicine · 1992
Bone densitometry in patients with multiple myeloma.
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Mariette X, Khalifa P, Ravaud P, Frija J, Laval-Jeantet M, Chastang C, Brouet J C, Fermand J P
Аннотация
PURPOSE, PATIENTS, AND METHODS: We performed dual-energy x-ray absorptiometry in 10 selected patients with aggressive multiple myeloma in whom substantial tumor mass reduction was achieved after high-dose chemoradiotherapy followed by autologous blood stem cell transplantation.
RESULTS: In most cases, bone mineral density (BMD) of the spine was initially low (Mean Z score: -2.69, SEM 0.76) and dramatically increased after treatment (mean increase 16.4%; 7.7% with 95% confidence interval 2.2 to 12.2, excluding one patient whose spine BMD increased by 94.8%). In contrast, skeletal roentgenograms, computed tomographic scans, and magnetic resonance imaging did not reveal any significant improvement of patients' bone lesions.
CONCLUSIONS: In patients with multiple myeloma, bone densitometry could be a useful way to assess the efficacy of treatment on bone status.
RESULTS: In most cases, bone mineral density (BMD) of the spine was initially low (Mean Z score: -2.69, SEM 0.76) and dramatically increased after treatment (mean increase 16.4%; 7.7% with 95% confidence interval 2.2 to 12.2, excluding one patient whose spine BMD increased by 94.8%). In contrast, skeletal roentgenograms, computed tomographic scans, and magnetic resonance imaging did not reveal any significant improvement of patients' bone lesions.
CONCLUSIONS: In patients with multiple myeloma, bone densitometry could be a useful way to assess the efficacy of treatment on bone status.
Предметные рубрики MeSH
Absorptiometry, PhotonAdultAntineoplastic Combined Chemotherapy ProtocolsBlood Component TransfusionBlood Transfusion, AutologousBone DensityCombined Modality TherapyFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedMultiple MyelomaNeoplasm StagingRadionuclide ImagingSensitivity and SpecificityStem Cell TransplantationTomography, X-Ray ComputedTreatment OutcomeWhole-Body Irradiation