Electroacupuncture reshapes the microbial co-occurrence networks related to the behavioral and psychological symptoms of dementia in Alzheimer's disease.

Microbial keystone species and gut microbiota composition are highly variable during the pathological development of the behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD). Age stratification reveals stage-specific gut microbial signatures in AD-related BPSD. This study highlights the efficacy of electroacupuncture in regard to altering the intestinal microbial landscape in AD-related BPSD and provides novel insights into the application of phased targeted electroacupuncture interventions in the future.