International journal of surgery case reports · 2025
Eosinophilic angiocentric fibrosis: A case report and a review of the literature.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Alotaibi Jood K, Alkhaldi Raghad A, Alotaibi Naif H, Mumtaz R M, Dababo M Anas
Аннотация
BACKGROUND: Eosinophilic Angiocentric Fibrosis (EAF) is a rare inflammatory condition affecting the upper respiratory and sinonasal tracts. This study aims to elaborate on the clinical and pathological features of a patient with extensive, rare EAF involving the sinonasal tract, subglottic region, and orbit.
CASE PRESENTATION: A fifty-five-year-old female patient with a known case of bronchial asthma, hypothyroidism, and IgG-4-related necrotizing blepharitis presented to our clinic with a 14-year history of bilateral nasal obstruction and post-nasal drip despite medical and surgical intervention. Rhinoscopy revealed fibrosis and adhesion of the nasal cavity and nasopharynx, along with grade I subglottic stenosis. Functional endoscopic sinus surgery was performed to relieve her symptoms and obtain a specimen confirming the diagnosis of EAF.
DISCUSSION: Given the wide variety of differential diagnoses for bilateral nasal obstruction, imaging and histopathological evaluation are necessary to diagnose EAF. The characteristic onion-skin pattern reflecting the perivascular eosinophil-rich inflammatory infiltrate with subsequent concentric fibrosis is the gold standard in diagnosing these patients.
CONCLUSION: Despite advancements in clinical practice, a clear management guideline for patients with EAF has not yet been established. In our paper, we pool our management approach with the literature.
CASE PRESENTATION: A fifty-five-year-old female patient with a known case of bronchial asthma, hypothyroidism, and IgG-4-related necrotizing blepharitis presented to our clinic with a 14-year history of bilateral nasal obstruction and post-nasal drip despite medical and surgical intervention. Rhinoscopy revealed fibrosis and adhesion of the nasal cavity and nasopharynx, along with grade I subglottic stenosis. Functional endoscopic sinus surgery was performed to relieve her symptoms and obtain a specimen confirming the diagnosis of EAF.
DISCUSSION: Given the wide variety of differential diagnoses for bilateral nasal obstruction, imaging and histopathological evaluation are necessary to diagnose EAF. The characteristic onion-skin pattern reflecting the perivascular eosinophil-rich inflammatory infiltrate with subsequent concentric fibrosis is the gold standard in diagnosing these patients.
CONCLUSION: Despite advancements in clinical practice, a clear management guideline for patients with EAF has not yet been established. In our paper, we pool our management approach with the literature.