Phytomedicine : international journal of phytotherapy and phytopharmacology · 2014
Antileishmanial activity of essential oil from Chenopodium ambrosioides and its main components against experimental cutaneous leishmaniasis in BALB/c mice.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Monzote L, Pastor J, Scull R, Gille L
Аннотация
UNLABELLED: Chenopodium ambrosioides have been used during centuries by native people to treat parasitic diseases.
AIMS OF THE STUDY: To compare the in vivo anti-leishmanial activity of the essential oil (EO) from C. ambrosioides and its major components (ascaridole, carvacrol and caryophyllene oxide).
MATERIALS AND METHODS: Anti-leishmanial effect was evaluated in BALB/c mice infected with Leishmania amazonensis and treated with the EO, main compounds and artificial mix of pure components by intralesional route at 30 mg/kg every 4 days during 14 days. Diseases progression and parasite burden in infected tissues were determined.
RESULTS: EO prevented lesion development compared (p<0.05) with untreated animals and treated with vehicle. In addition, the efficacy of EO was also statistically superior (p<0.05) compared with the glucantime-treated animals. No potential effects were observed with pure components treatment. Mix of pure compounds cause death of animals after 3 days of treatment.
CONCLUSIONS: Our results demonstrate the superiority of EO against experimental cutaneous leishmaniasis caused by L. amazonensis.
AIMS OF THE STUDY: To compare the in vivo anti-leishmanial activity of the essential oil (EO) from C. ambrosioides and its major components (ascaridole, carvacrol and caryophyllene oxide).
MATERIALS AND METHODS: Anti-leishmanial effect was evaluated in BALB/c mice infected with Leishmania amazonensis and treated with the EO, main compounds and artificial mix of pure components by intralesional route at 30 mg/kg every 4 days during 14 days. Diseases progression and parasite burden in infected tissues were determined.
RESULTS: EO prevented lesion development compared (p<0.05) with untreated animals and treated with vehicle. In addition, the efficacy of EO was also statistically superior (p<0.05) compared with the glucantime-treated animals. No potential effects were observed with pure components treatment. Mix of pure compounds cause death of animals after 3 days of treatment.
CONCLUSIONS: Our results demonstrate the superiority of EO against experimental cutaneous leishmaniasis caused by L. amazonensis.
Предметные рубрики MeSH
AnimalsAntiprotozoal AgentsChenopodium ambrosioidesCyclohexane MonoterpenesCymenesFemaleInjections, IntralesionalLeishmaniaLeishmaniasis, CutaneousMeglumineMeglumine AntimoniateMiceMice, Inbred BALB CMonoterpenesOils, VolatileOrganometallic CompoundsPeroxidesPlant OilsPolycyclic SesquiterpenesSesquiterpenes