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Войти в исследования European journal of neurology · 2010
Lack of association of LINGO1 rs9652490 and rs11856808 SNPs with familial essential tremor.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Lorenzo-Betancor O, García-Martín E, Cervantes S, Agúndez J A G, Jiménez-Jiménez F J, Alonso-Navarro H, Luengo A, Coria F, Lorenzo E, Irigoyen J, Pastor P
Аннотация
BACKGROUND: Essential tremor (ET) is a frequent movement disorder with a substantial family aggregation. A genome-wide association study has recently shown that LINGO1 gene variants are associated with increased risk of ET.
METHODS: We intended to replicate these findings by genotyping rs9652490 and rs11856808 in a series of 226 familial ET subjects and 1117 healthy controls from referral movement disorder clinics in Spain.
RESULTS: We were unable to replicate the association between LINGO1 variants and familial ET.
CONCLUSIONS: Our results indicate that the LINGO1 variants analyzed are not a major risk factor for developing familial ET in our population, which suggests the existence of other unknown genetic risk factors responsible for familial ET in the Spanish population.
METHODS: We intended to replicate these findings by genotyping rs9652490 and rs11856808 in a series of 226 familial ET subjects and 1117 healthy controls from referral movement disorder clinics in Spain.
RESULTS: We were unable to replicate the association between LINGO1 variants and familial ET.
CONCLUSIONS: Our results indicate that the LINGO1 variants analyzed are not a major risk factor for developing familial ET in our population, which suggests the existence of other unknown genetic risk factors responsible for familial ET in the Spanish population.