[Stereometric evaluation of the myocardial cardiomyocyte-capillary ratio in emotional and pain-induced stress after administration of thiamine and nicotinamide].

The effects of thiamin and nicotinamide on left-ventricular myocardial cardiomyocyte/capillary ratio at the outcome of lasting emotional/painful stress have been examined in rats, using stereometric techniques. Thiamin is shown to be capable of preventing, to a certain extent, myocardial microcirculatory disturbances and, hence, preventing oxygen deficiency. Preventive administration of nicotinamide cannot, on the contrary, prevent microcirculatory disturbances. Specific action of vitamins seems to be determined by the mechanisms of glucocorticoid secretion stimulation (nicotinamide) and antistress effect (thiamin). It is proposed that thiamin may be used to prevent stress-related myocardial damage.