HPB : the official journal of the International Hepato Pancreato Biliary Association · 2012
Prognostic value of the lymph node ratio after resection of periampullary carcinomas.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Farid Shahid G, Falk Gavin A, Joyce Daniel, Chalikonda Sricharan, Walsh R Matthew, Smith Andrew M, Morris-Stiff Gareth
Аннотация
BACKGROUND: Data have indicated that the lymph node ratio (LNR) may be a better prognostic indicator than lymph node status in pancreatic cancer.
OBJECTIVES: To analyse the value of the LNR in patients undergoing resection for periampullary carcinomas.
METHODS: A cut off value of 0.2 was assigned to the LNR in accordance with published studies. The impact of histopathological factors including a LNR was analysed using Kaplan-Meier and Cox regression methods.
RESULTS: In total, 551 patients undergoing a resection (January 2000 to December 2010) were analysed. The median lymph node yield was 15, and 198 (34%) patients had a LNR > 0.2. In patients with a LNR of > 0.2, the median overall survival (OS) was 18 versus 33 months in patients with an LNR < 0.2 (P < 0.001). Univariate analysis demonstrated a LNR > 0.2, T and N stage, vascular or perineural invasion, grade and resection margin status to be significantly associated with OS. On multivariate analysis, only a LNR > 0.2, vascular or perineural invasion and margin positivity remained significant. In N1 disease, a LNR was able to distinguish survival in patients with a similar lymph node burden, and correlated with more aggressive tumour pathological variables.
CONCLUSION: A LNR > 0.2, and not lymph note status, is an independent prognostic factor for OS indicating the LNR should be utilized in outcome stratification.
OBJECTIVES: To analyse the value of the LNR in patients undergoing resection for periampullary carcinomas.
METHODS: A cut off value of 0.2 was assigned to the LNR in accordance with published studies. The impact of histopathological factors including a LNR was analysed using Kaplan-Meier and Cox regression methods.
RESULTS: In total, 551 patients undergoing a resection (January 2000 to December 2010) were analysed. The median lymph node yield was 15, and 198 (34%) patients had a LNR > 0.2. In patients with a LNR of > 0.2, the median overall survival (OS) was 18 versus 33 months in patients with an LNR < 0.2 (P < 0.001). Univariate analysis demonstrated a LNR > 0.2, T and N stage, vascular or perineural invasion, grade and resection margin status to be significantly associated with OS. On multivariate analysis, only a LNR > 0.2, vascular or perineural invasion and margin positivity remained significant. In N1 disease, a LNR was able to distinguish survival in patients with a similar lymph node burden, and correlated with more aggressive tumour pathological variables.
CONCLUSION: A LNR > 0.2, and not lymph note status, is an independent prognostic factor for OS indicating the LNR should be utilized in outcome stratification.
Предметные рубрики MeSH
AgedAmpulla of VaterCarcinomaChi-Square DistributionCommon Bile Duct NeoplasmsEnglandFemaleHumansKaplan-Meier EstimateLymph Node ExcisionLymph NodesLymphatic MetastasisMaleMiddle AgedMultivariate AnalysisNeoplasm, ResidualOhioPancreatic NeoplasmsPancreaticoduodenectomyProportional Hazards ModelsRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment Outcome