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Войти в исследования Prognosis of a deep excision margin within or beyond subcutaneous fat for invasive acral melanoma of the sole: A multi-institutional retrospective study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Koizumi Shigeru, Yamazaki Naoya, Ichigozaki Yuki, Kitagawa Hiroshi, Kiniwa Yukiko, Sato Sayuri, Takai Toshihiro, Doi Reiichi, Ito Takamichi, Yasuda Masahito, Kuwatsuka Yutaka, Maekawa Takeo, Asai Jun, Miyagawa Takuya, Matsushita Shigeto, Funakoshi Takeru, Yamamoto Yosuke, Inozume Takashi, Kishi Akiko, Takenouchi Tatsuya, Kokubu Hiraku, Ito Shusaku, Umeda Yoshiyasu, Yamamoto Yuki, Ishizuki Shoichiro, Iino Shiro, Uchi Hiroshi, Nakagawa Tomoe, Inafuku Kazuhiro, Haga Takahiro, Kaneko Takahide, Nakagawa Masahiro, Arima Masaru, Hoashi Toshihiko, Hiura Azusa, Nagai Makoto, Manabe Keiko, Ishikawa Masashi, Asagoe Kenji, Iwasawa Utsugi, Kadono Takafumi, Hatta Naohito, Minami Shoichiro, Nakano Eiji, Ogata Dai, Fukushima Satoshi, Uhara Hisashi, Nakama Kenta, Nakamura Yasuhiro, Japanese Association of Dermatologic Surgery
Аннотация
METHODS: In this multi-institutional retrospective study, survival was compared between 2 groups of patients: those with tumors excised within (S group) and those beyond the subcutaneous fat (D group).
RESULTS: In total, 464 patients were included. Cox multivariable analyses showed that the depth of the deep excision margin was not associated with local recurrence-free survival, overall survival, or distant metastasis-free survival (hazard ratios of 1.20, P = .36; 1.10, P = .66; and 1.42, P = .05, respectively). However, excision beyond the subcutaneous fat was negatively associated with disease-free survival (hazard ratio 1.45, P = .02). After propensity score matching (both groups, n = 139), no significant differences were observed in survival outcomes between the S and D groups (5-year local recurrence-free survival: 72.8 vs 66.8%, P = .55; 5-year disease-free survival: 55.3 vs 43.7%, P = .24; 5-year overall survival: 76.2 vs 73.2%, P = .52; 5-year distant metastasis-free survival: 63.3 vs 54.1%, P = .13). Subgroup analysis of American Joint Committee on Cancer stages revealed no significant differences in survival outcomes between the 2 groups at any stage.
CONCLUSION: Wide local excision beyond the subcutaneous fat was not associated with survival benefit of acral melanoma of the sole. Excision within the subcutaneous fat may represent the optimal deep margin.