MedElevator
Войти в исследования Dental materials : official publication of the Academy of Dental Materials · 2026
Optimizing orthodontic adhesives with bioinspired tannic acid: An integrated approach to improve Bond strength and bacterial inhibition without compromising conversion and cytocompatibility.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ding Xiaoqian, Li Xin, Yiu Cynthia Kar Yung, Shan Zhiyi
Аннотация
OBJECTIVE: To evaluate the effect of incorporating tannic acid (TA) into a moisture-insensitive orthodontic primer on wet-bonding performance, resistance to cariogenic bacteria, cytocompatibility, and degree of conversion.
METHODS: Two hundred extracted human premolars were assigned to four groups: a control using a commercial moisture-insensitive primer (MIP; 3 M, USA) and three TA-modified primers with TA incorporated into MIP at 0.04, 0.08, or 0.12 mg/μL. Cytocompatibility was assessed via CCK-8 assay, and degree of conversion (DC) was measured. Under simulated moisture contamination, bracket shear bond strength (SBS) and the adhesive remnant index (ARI) were measured before and after 2000 thermocycles. Bonding interfaces and enamel surfaces were examined using scanning electron microscopy (SEM). Resistance against Streptococcus mutans (S. mutans) was determined through colony-forming unit (CFU) counts, crystal violet (CV) staining, and SEM biofilm visualization.
RESULTS: Cytocompatibility and DC were comparable across all groups. Under simulated moist conditions, all TA-modified primers achieved significantly higher bracket SBS than the control both immediately and after thermal cycling, with the 0.08 mg/μL TA formulation showing the greatest improvement. Experimental groups yielded higher ARI scores than the control, with no enamel defects observed. The 0.08 mg/μL formulation significantly suppressed S. mutans, reducing CFUs and biofilm accumulation.
SIGNIFICANCE: Incorporating 0.08 mg/μL TA into the MIP creates a dual-function orthodontic primer that improves bond durability in moist conditions while simultaneously providing resistance to Streptococcus mutans, without compromising cytocompatibility or polymerization efficiency. This formulation offers a promising clinical solution for reducing bracket failure and preventing white spot lesions in orthodontic patients.
METHODS: Two hundred extracted human premolars were assigned to four groups: a control using a commercial moisture-insensitive primer (MIP; 3 M, USA) and three TA-modified primers with TA incorporated into MIP at 0.04, 0.08, or 0.12 mg/μL. Cytocompatibility was assessed via CCK-8 assay, and degree of conversion (DC) was measured. Under simulated moisture contamination, bracket shear bond strength (SBS) and the adhesive remnant index (ARI) were measured before and after 2000 thermocycles. Bonding interfaces and enamel surfaces were examined using scanning electron microscopy (SEM). Resistance against Streptococcus mutans (S. mutans) was determined through colony-forming unit (CFU) counts, crystal violet (CV) staining, and SEM biofilm visualization.
RESULTS: Cytocompatibility and DC were comparable across all groups. Under simulated moist conditions, all TA-modified primers achieved significantly higher bracket SBS than the control both immediately and after thermal cycling, with the 0.08 mg/μL TA formulation showing the greatest improvement. Experimental groups yielded higher ARI scores than the control, with no enamel defects observed. The 0.08 mg/μL formulation significantly suppressed S. mutans, reducing CFUs and biofilm accumulation.
SIGNIFICANCE: Incorporating 0.08 mg/μL TA into the MIP creates a dual-function orthodontic primer that improves bond durability in moist conditions while simultaneously providing resistance to Streptococcus mutans, without compromising cytocompatibility or polymerization efficiency. This formulation offers a promising clinical solution for reducing bracket failure and preventing white spot lesions in orthodontic patients.