Medicina clinica · 2000
[Clinical manifestations of heterozygote familial hypercholesterolemia in Spain. Study of 301 cases from the central and northern areas].
Сравнительное исследованиеАннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Garcés C, Rodríguez Artalejo F, Serrano A, González Bonillo J, Almagro F, Garrido J A, Zúñiga M, de Oya M
Аннотация
RATIONALE: To characterize clinical manifestations of familial hypercholesterolemia (FH) in Spain.
PATIENTS AND METHODS: A group of 301 cases of FH from central and north regions of Spain.
RESULTS: With a mean (SD) cholesterol level of 346 (58) mg/dl, only 7.6% of the patients have xanthomas and 20% ischaemic heart disease. 51% have a familial history of ischaemic heart disease.
CONCLUSIONS: Different from the results of literature, xanthomas are very infrequent in FH in Spain, so diagnosis should be suspected from other data. The high prevalence of familial history of ischaemic heart disease supports the usefulness of this feature as a marker for diagnosis and prevention.
PATIENTS AND METHODS: A group of 301 cases of FH from central and north regions of Spain.
RESULTS: With a mean (SD) cholesterol level of 346 (58) mg/dl, only 7.6% of the patients have xanthomas and 20% ischaemic heart disease. 51% have a familial history of ischaemic heart disease.
CONCLUSIONS: Different from the results of literature, xanthomas are very infrequent in FH in Spain, so diagnosis should be suspected from other data. The high prevalence of familial history of ischaemic heart disease supports the usefulness of this feature as a marker for diagnosis and prevention.