A core outcome set for pituitary surgery research: an international delphi consensus study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Valetopoulou Alexandra, Newall Nicola, Khan Danyal Z, Borg Anouk, Bouloux Pierre M G, Bremner Fion, Buchfelder Michael, Cudlip Simon, Dorward Neil, Drake William M, Fernandez-Miranda Juan C, Fleseriu Maria, Geltzeiler Mathew, Ginn Joy, Gurnell Mark, Harris Steve, Jaunmuktane Zane, Korbonits Márta, Kosmin Michael, Koulouri Olympia, Horsfall Hugo Layard, Mamelak Adam N, Mannion Richard, McBride Pat, McCormack Ann I, Melmed Shlomo, Miszkiel Katherine A, Raverot Gerald, Santarius Thomas, Schwartz Theodore H, Serrano Inma, Zada Gabriel, Baldeweg Stephanie E, Marcus Hani J, Kolias Angelos G, PitCOP Collaborators
Аннотация
METHODS: Thirty-three outcomes were identified through a systematic review of pituitary adenoma surgery outcomes and a study on patient-reported measures. These were presented in an online survey to healthcare professionals (HCPs), patients and caregivers. In the first round, participants scored each outcome's importance on a 5-point scale (1-strongly disagree; 5-strongly agree) and could also suggest additional outcomes, which were reviewed and, if appropriate, added to existing domains. In the second round, participants re-scored the updated the list, considering group median and interquartile range scores from the previous round. Outcomes with a median score of 5 were included in the COS. A final live online consensus meeting discussed and voted on borderline outcomes (median scores 3-4).
RESULTS: The first round received 95 responses (52% HCPs, 48% patients/caregivers). Of the 33 outcomes, 16 received a median score of 5 (strongly agree), three received 4.5 and 14 received 4 (agree). Round two received 87 responses (52% HCPs, 48% patients and caregivers). Of the 33 outcomes, 14 received a median ranking of 5, two received 4.5, 15 received 4 and two received 3 (neutral). The live meeting (attended by 12 participants: 5 HCPs, 6 patients, 1 caregiver), reached consensus on the final COS, which includes 7 domains: short-term surgical outcomes; nasal outcomes; ophthalmic outcomes; endocrine outcomes; quality of life and psychological outcomes; other short-term outcomes; and disease control outcomes.
CONCLUSION: We advocate for use of the COS in future pituitary surgery research.