European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
Retrospective analysis of different application methods in intratympanic glucocorticoid therapy for treatment of idiopathic SSNHL: A comparative outcome study.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Schmit C, Keller F, Gottfried T, Santer M, Tröger A, Kloppenburg M, Klarer J, Stenzl A, Schmutzhard J, Hofauer B, Dejaco D
Аннотация
PURPOSE: Glucocorticoids for sudden sensorineural hearing loss (SSNHL) can be administered systemically or via intratympanic injection. This study evaluates the impact of different intratympanic injection techniques on patient outcomes.
METHODS: A retrospective analysis was conducted on patients diagnosed with idiopathic SSNHL (January 2008-May 2023). Patients were grouped by application technique: (1) transtympanic injection under local anesthesia (TI), (2) CO2 laser paracentesis under general anesthesia (LP), and (3) VT application under general anesthesia (VT). Primary outcomes included hearing improvement and tympanic membrane perforation closure time.
RESULTS: The study included 99 patients: 28 with TI, 34 with VT, and 37 with LP. Groups showed no significant differences in sex, affected side, therapy initiation interval, pretreatment type, preoperative BCPTA4, subjective improvement, or treatment-related pain (all p > 0.1). Hearing thresholds improved significantly in the LP and VT groups with large (d = 0.832, p < 0.001) and medium (d = 0.513, p = 0.01) effect sizes, respectively, but not in the TI group (d = 0.294, p = 0.137). Tympanic membrane closure time differed significantly among groups (p < 0.001).
CONCLUSIONS: LP and VT significantly improved hearing thresholds in SSNHL patients. LP demonstrated the highest efficacy, consistent results across SSNHL severities, and the fastest tympanic membrane closure, making it the preferred method.
METHODS: A retrospective analysis was conducted on patients diagnosed with idiopathic SSNHL (January 2008-May 2023). Patients were grouped by application technique: (1) transtympanic injection under local anesthesia (TI), (2) CO2 laser paracentesis under general anesthesia (LP), and (3) VT application under general anesthesia (VT). Primary outcomes included hearing improvement and tympanic membrane perforation closure time.
RESULTS: The study included 99 patients: 28 with TI, 34 with VT, and 37 with LP. Groups showed no significant differences in sex, affected side, therapy initiation interval, pretreatment type, preoperative BCPTA4, subjective improvement, or treatment-related pain (all p > 0.1). Hearing thresholds improved significantly in the LP and VT groups with large (d = 0.832, p < 0.001) and medium (d = 0.513, p = 0.01) effect sizes, respectively, but not in the TI group (d = 0.294, p = 0.137). Tympanic membrane closure time differed significantly among groups (p < 0.001).
CONCLUSIONS: LP and VT significantly improved hearing thresholds in SSNHL patients. LP demonstrated the highest efficacy, consistent results across SSNHL severities, and the fastest tympanic membrane closure, making it the preferred method.