Revista da Sociedade Brasileira de Medicina Tropical · 2024
TNF-expressing CD1d+ monocytes are associated with the activation of CD4- CD8- T cells in patients with Chagas cardiomyopathy.
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Koh Carolina Cattoni, Velikkakam Teresiama, Neves Eula Graciele Amorim, Medeiros Nayara Ingrid, Gomes Juliana Assis, Silva Silvana de Araújo, Gollob Kenneth John, Nunes Maria do Carmo Pereira, Dutra Walderez Ornelas
Аннотация
BACKGROUND: Chagas disease cardiomyopathy is characterized by intense immune activation, with double-negative (DN) T cells as key producers of inflammatory cytokines. CD1d is an antigen-presenting molecule involved in the activation of DN T cells.
METHODS: We characterized CD1d+ monocytes from patients with cardiac (CARD) and indeterminate (IND) disease using flow cytometry.
RESULTS: CARD CD1d+ monocytes exhibited higher expression of TNF, TNF-receptor, PDL-1, and Fas-L compared to those from IND. These monocytes correlated with TNF expression by DN T-cells in CARD but not in IND.
CONCLUSIONS: CD1d+ monocytes from CARD are inflammatory and associated with DN T-cell activation, confirming that CD1d is a target for modulating inflammation in Chagas cardiomyopathy.
METHODS: We characterized CD1d+ monocytes from patients with cardiac (CARD) and indeterminate (IND) disease using flow cytometry.
RESULTS: CARD CD1d+ monocytes exhibited higher expression of TNF, TNF-receptor, PDL-1, and Fas-L compared to those from IND. These monocytes correlated with TNF expression by DN T-cells in CARD but not in IND.
CONCLUSIONS: CD1d+ monocytes from CARD are inflammatory and associated with DN T-cell activation, confirming that CD1d is a target for modulating inflammation in Chagas cardiomyopathy.