Journal of the American Academy of Dermatology · 2002
Three-dimensional analysis of a calciphylaxis plaque: clues to pathogenesis.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Au Sheila, Crawford Richard I
Аннотация
BACKGROUND: Calciphylaxis is a rare, life-threatening disorder associated with chronic renal failure, presenting with ulcerating plaques leading to death by sepsis in 60% of patients. Calcification of subcutaneous arterioles, thromboses, and extravascular calcification have been demonstrated in incisional biopsy specimens. However, the sequence of these pathologic events is unknown.
OBJECTIVE: We examined a calciphylaxis plaque to document the wave of pathologic change from its center to its periphery.
METHODS: A calciphylaxis plaque was excised postmortem from a female patient. It was examined histologically along 12 radii from the center of the lesion to its periphery.
RESULTS: Calcification of small subcutaneous vessels was present in all histologically abnormal sections and extended further peripherally than extravascular calcification by up to 3.0 cm and further than subcutaneous thrombosis by up to 1.5 cm.
CONCLUSION: Vascular mural calcification is an early and essential process in the development of a calciphylaxis plaque.
OBJECTIVE: We examined a calciphylaxis plaque to document the wave of pathologic change from its center to its periphery.
METHODS: A calciphylaxis plaque was excised postmortem from a female patient. It was examined histologically along 12 radii from the center of the lesion to its periphery.
RESULTS: Calcification of small subcutaneous vessels was present in all histologically abnormal sections and extended further peripherally than extravascular calcification by up to 3.0 cm and further than subcutaneous thrombosis by up to 1.5 cm.
CONCLUSION: Vascular mural calcification is an early and essential process in the development of a calciphylaxis plaque.