Internal medicine (Tokyo, Japan) · 2010
Primary bilateral adrenal diffuse large B-cell lymphoma demonstrating adrenal failure.
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Horiguchi Kazuhiko, Hashimoto Koshi, Hashizume Masayuki, Masuo Takashige, Suto Mariko, Okajo Jun, Handa Hiroshi, Kaneko Yoriaki, Yokoo Hideaki, Sasaki Atsushi, Okada Shuichi, Yamada Masanobu, Tsukamoto Norifumi, Nojima Yoshihisa, Nakazato Yoichi, Mori Masatomo
Аннотация
Primary adrenal lymphoma (PAL) is extremely rare although involvement of malignant lymphoma into adrenals is common. We report a case of a 58-year-old man with bilateral PAL who demonstrated adrenal insufficiency. Primary large B-cell lymphoma was proven by a computed tomography-guided needle biopsy of the adrenal tumor. Although a complete remission was once achieved by combination chemotherapy plus rituximab, a recurrence occurred with brain metastasis leading to his death. We concluded that PAL should be considered as a possible cause of bilateral adrenal incidentalomas with progressive adrenal insufficiency.
Предметные рубрики MeSH
Adrenal Gland NeoplasmsAdrenal InsufficiencyAntibodies, Monoclonal, Murine-DerivedAntineoplastic Combined Chemotherapy ProtocolsBrain NeoplasmsCisplatinCombined Modality TherapyCyclophosphamideCytarabineDexamethasoneDoxorubicinFatal OutcomeHumansIncidental FindingsLymphoma, Large B-Cell, DiffuseMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasms, Multiple PrimaryPrednisoneRituximabVincristine