Psychoneuroendocrinology · 2025
Psychological and immunological benefits of eye movement desensitization and reprocessing in hashimoto thyroiditis: Preliminary findings from a randomized controlled trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Macarenco Maria-Magdalena, Opariuc-Dan Cristian, Georgescu Teodora, Căciuloiu Livia
Аннотация
OBJECTIVE: This study examined the effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) in improving psychological functioning and modulating immune markers in adults with Hashimoto's thyroiditis (HT), a chronic autoimmune disorder increasingly linked to early trauma.
METHOD: In a randomized controlled trial, 91 adults with HT were assigned to EMDR plus treatment-as-usual (TAU), placebo plus TAU, or TAU alone. The EMDR protocol focused on processing ten distressing memories predating illness onset. Outcomes included anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) levels, and measures of depression, anxiety, stress, dissociation, alexithymia, trait anger, emotion regulation, and quality of life, assessed at baseline, posttreatment, and 3-month follow-up.
RESULTS: EMDR led to significant improvements in dissociation, alexithymia, depression, anxiety, stress, trait anger, and emotion regulation, along with enhanced quality of life. These effects were maintained at follow-up and generally exceeded those of placebo or TAU. A significant reduction in anti-TPO levels was also observed in the EMDR group, although between-group effects at follow-up did not remain significant after correction for multiple comparisons. No significant differences were found in anti-TG levels.
CONCLUSION: EMDR may offer a clinically relevant adjunctive intervention for individuals with HT, reducing psychological distress and potentially influencing immune activity. Findings on immunomodulation are preliminary and warrant further investigation in larger trials.
METHOD: In a randomized controlled trial, 91 adults with HT were assigned to EMDR plus treatment-as-usual (TAU), placebo plus TAU, or TAU alone. The EMDR protocol focused on processing ten distressing memories predating illness onset. Outcomes included anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) levels, and measures of depression, anxiety, stress, dissociation, alexithymia, trait anger, emotion regulation, and quality of life, assessed at baseline, posttreatment, and 3-month follow-up.
RESULTS: EMDR led to significant improvements in dissociation, alexithymia, depression, anxiety, stress, trait anger, and emotion regulation, along with enhanced quality of life. These effects were maintained at follow-up and generally exceeded those of placebo or TAU. A significant reduction in anti-TPO levels was also observed in the EMDR group, although between-group effects at follow-up did not remain significant after correction for multiple comparisons. No significant differences were found in anti-TG levels.
CONCLUSION: EMDR may offer a clinically relevant adjunctive intervention for individuals with HT, reducing psychological distress and potentially influencing immune activity. Findings on immunomodulation are preliminary and warrant further investigation in larger trials.