Annals of the rheumatic diseases · 1984
Lymphoproliferative malignancy in rheumatoid arthritis: a study of 20 cases.
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Symmons D P, Ahern M, Bacon P A, Hawkins C F, Amlot P L, Jones E L, Prior P, Scott D L
Аннотация
A series of 20 patients with definite or classical rheumatoid arthritis who subsequently developed a lymphoproliferative malignancy are described. The mean time between the onset of the 2 diseases was 13.2 years. A wide range of types of non-Hodgkin's lymphoma and Hodgkin's disease were found; there were no unusual histological features in the lymphomas. Although many of the patients had had gold, penicillamine, and other second-line drugs, none of them had received cytotoxic drugs, and there was no evidence that therapy was a cause of their malignancies. The likely cause of the association is a predisposition to both diseases.