What's new in acne and inflammation?

Acne is a disease that leaves physiological as well as physical scars. As we attempt to understand this complicated disease, new research challenges our traditional understanding that the microcomedone is the initial step in the development of the acne lesion. Recent evidence suggests that subclinical inflammation is the primary event in lesion development and that inflammation persists throughout the lesion life-cycle. Therefore, all types of acne should be considered "inflammatory" acne.