Early detection of pulmonary mucormycosis using microbial cell-free DNA sequencing of bronchoalveolar lavage fluid in neutropenic Hosts: A report of two cases.

Mucormycosis is an aggressive fungal infection characterized by angioinvasion, tissue necrosis, and high mortality rates. Microbial cell-free DNA (mcfDNA) sequencing provides rapid, non-invasive detection of microbial genetic material to guide diagnosis and treatment. We describe 2 cases of immunocompromised patients with invasive mucormycosis wherein mcfDNA sequencing significantly expedited diagnosis, allowing early surgical intervention and antimicrobial treatment.