Oncoimmunology · 2015
Lectin-like transcript 1 is a marker of germinal center-derived B-cell non-Hodgkin's lymphomas dampening natural killer cell functions.
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Germain Claire, Guillaudeux Thierry, Galsgaard Elisabeth D, Hervouet Catherine, Tekaya Nedra, Gallouet Anne-Sophie, Fassy Julien, Bihl Franck, Poupon Gwenola, Lazzari Anne, Spee Pieter, Anjuère Fabienne, Pangault Céline, Tarte Karin, Tas Patrick, Xerri Luc, Braud Veronique M
Аннотация
Non-Hodgkin's lymphomas (NHLs) are malignant neoplasms which are clinically and biologically diverse. Their incidence is constantly increasing and despite treatment advances, there is a need for novel targeted therapies. Here, we identified Lectin-like transcript 1 (LLT1) as a biomarker of germinal center (GC)-derived B-cell NHLs. LLT1 identifies GC B cells in reactive tonsils and lymph nodes and its expression is maintained in B-cell NHLs which derive from GC, including Burkitt lymphoma (BL), follicular lymphoma (FL), and GC-derived diffuse large B-cell lymphoma (DLBCL). We further show that LLT1 expression by tumors dampens natural killer (NK) cell functions following interaction with its receptor CD161, uncovering a potential immune escape mechanism. Our results pinpoint LLT1 as a novel biomarker of GC-derived B-cell NHLs and as a candidate target for innovative immunotherapies.