Stem cell therapy for ischemic stroke.

This paper reviews the recent studies and development of stem cell therapy for ischemic stroke. Stem cells can differentiate into several types of mature cells, including neurons and glial cells. Stem cell transplantation, a promising therapy, can be able to facilitate functional recovery both in animal models and stroke patients. In this review, we introduce briefly the different types of endogenous stem cells and the transplantation of exogenous stem cells; in addition, we discuss the timing, dosage, route, and tracing of stem cell therapy for ischemic stroke in details. Finally, the clinical challenge and application of stem cells in future are also discussed.