Pathology oncology research : POR · 2013
A collaborative nationwide lymphoma study in Lebanon: incidence of various subtypes and analysis of associations with viruses.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Otrock Zaher K, Saab Jad, Aftimos Georges, Nasr Fady, Farhat Fadi S, Khairallah Saad, Abadjian Gérard, Ghosn Marwan, Sidani Hassan, Ibrahim Ahmad, Tawil Ayman, Ghorra Claude, Meguerian Zarouhie, Mokaddem Walid, Dayeh Walid, Salem Ziad, Chahine Georges, Bitar Nizar, Mugharbel Anas, Makdessi Joseph, Khater Christina, El Hajj Mirna, Abi Gerges Dany, Sfeir Charles, Kattan Joseph, Ibrahim Khaled, Saade Michel, Sadek Hussein, Mahfouz Rami A, Kharfan-Dabaja Mohamed A, Zaatari Ghazi, Bazarbachi Ali
Аннотация
Incidence of various Hodgkin (HL) and non-Hodgkin lymphoma (NHL) subtypes and association with viruses in Lebanon are not known. We undertook a nationwide study of 272 patients diagnosed with lymphoma in 2007. HL comprised 32.7 % (n = 89) of cases while NHL represented 67.3 % (n = 183). Consistent with the literature, nodular sclerosis was the most predominant HL subtype (n = 57/89). Among NHL, B-cell NHL represented 88 % (n = 161/183), T-cell NHL 9 % (n = 17/183), whereas in 2.7 % it was not classifiable. The B-cell NHL comprised predominantly diffuse large B-cell lymphoma (46 %) and follicular lymphoma (23 %). 81 cases were reviewed by a panel of pathologists with 87.6 % concordance rate. Serology was negative for hepatitis C in 122 tested cases. HIV was positive in 2 cases. Two adult T-cell leukemia/lymphoma were HTLV-I positive. EBV IgG were positive in 88.5 % of cases. 38 EBV seropositive cases [27 NHL (24 B-cell, 3 T-cell) and 11 HL] were studied for EBV genome expression using EBV-encoded RNA (EBER)-in situ hybridization. EBER expression was positive in 8 (21 %) cases (6 HL, 2 T-cell NHL). The distribution of lymphoma subtypes in Lebanon appears similar to that of Western countries. The high rate of EBV positivity in HL and T-cell lymphoma by EBER deserves further investigation.