Current opinion in allergy and clinical immunology · 2012
The role of interleukin-1 in allergy-related disorders.
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Krause Karoline, Metz Martin, Makris Michael, Zuberbier Torsten, Maurer Marcus
Аннотация
PURPOSE OF REVIEW: Interleukin-1β (IL-1β) is a potent proinflammatory cytokine, which is involved in many inflammatory conditions including autoinflammatory and allergic disorders. This review provides insights into recent advances of our understanding of the pathogenesis of IL-1β-associated allergy-related disorders.
RECENT FINDINGS: In autoinflammatory as well as allergic diseases such as contact hypersensitivity, atopic dermatitis and bronchial asthma, dysfunctional inflammasome processing has been demonstrated to account for IL-1β-induced inflammation. IL-1-neutralizing drugs have been shown to completely suppress or markedly reduce inflammatory responses in clinical studies and experimental models of urticarial autoinflammatory diseases as well as common allergic disorders.
SUMMARY: The recent findings support a crucial role for IL-1β and inflammasome components in a variety of allergy-related disorders.
RECENT FINDINGS: In autoinflammatory as well as allergic diseases such as contact hypersensitivity, atopic dermatitis and bronchial asthma, dysfunctional inflammasome processing has been demonstrated to account for IL-1β-induced inflammation. IL-1-neutralizing drugs have been shown to completely suppress or markedly reduce inflammatory responses in clinical studies and experimental models of urticarial autoinflammatory diseases as well as common allergic disorders.
SUMMARY: The recent findings support a crucial role for IL-1β and inflammasome components in a variety of allergy-related disorders.