Медицинская библиотека · Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology · 2008

[Expression of TGF-beta receptors in CD8+ T cells of oral lichen planus].

Lei Lei, Yu Miao, Gao Xin-Yu, Zhou Xu-Long, Zhan Li-Hua

СтатьяПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

OBJECTIVE

To investigate the expression of TGF-beta receptors in CD8+ T cells of oral lichen planus (OLP).

METHODS

Immunohistochemical double labeling technique was used to examine the expression of TGF-betaR I and TGF-betaR II in CD8+ T cells of 28 OLP patients and in 10 controls. The results were compared between the two groups.

RESULTS

The double labeled cells were negative in controls. The positive rates of double labeled cells of CD8+/TGF-betaR I and CD8+/TGF-betaR II in OLP were (8.82 +/- 9.98)% and (1.11 +/- 2.94)% respectively.

CONCLUSIONS

The expression level of TGF-betaR II in CD8+ T cells of OLP did not increase compared with the controls, but the expression of TGF-betaR I increased. The results indicate the abnormal TGF-beta signal transduction in CD8+ T cells of OLP, which may contribute to the persistence of the chronic inflammation in OLP.

Для цитирования: Lei Lei, Yu Miao, Gao Xin-Yu, Zhou Xu-Long, Zhan Li-Hua. [Expression of TGF-beta receptors in CD8+ T cells of oral lichen planus].. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology. 2008.

Предметные рубрики MeSH

Adult CD8-Positive T-Lymphocytes Case-Control Studies Female Humans Lichen Planus, Oral Male Mouth Mucosa Protein Serine-Threonine Kinases Receptor, Transforming Growth Factor-beta Type I Receptor, Transforming Growth Factor-beta Type II Receptors, Transforming Growth Factor beta Signal Transduction

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