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Войти в исследования AACE endocrinology and diabetes · 2025
Relation of Serum α-Amylase Level With Glycated Hemoglobin and Trace Elements in Patients With Diabetes Mellitus.
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Mahmud Dewan Ashik, Islam Md Monirul, Rahaman Md Moshiur, Ripon Md Abdur Rahman, Quarishi Shamshad Begum, Hossain Mohammad Salim
Аннотация
INTRODUCTION: Diabetes mellitus (DM) arises from insufficiencies in insulin secretion and action. The pancreatic α-amylase enzyme is involved in starch metabolism and influences glycated hemoglobin (HbA1c) level. The current study examines relationships between blood glucose level, α-amylase activity, HbA1c, and several trace elements (Cu, Zn, and Mg).
CASE DESCRIPTION: Eighteen healthy control subjects and 31 patients with type 2 diabetes from both genders were recruited for this study. The enzymatic colorimetric method was used to assess serum glucose levels and α-amylase activity. The boronate affinity method and atomic absorption spectroscopy were used to measure HbA1c and trace elements, respectively.
DISCUSSION: In comparison to the control group, the diabetes groups' mean levels of α-amylase were slightly higher. The Cu level was significantly increased (P < 0.05) in the patient group, whereas Zn and Mg levels did not change significantly. HbA1c demonstrated a significant negative correlation (r = -0.394, P < 0.05) with α-amylase in patients with diabetes. The α-amylase also exhibited a negative correlation with glucose level in these patients. Cu level increased in hyperglycemia, and α-amylase negatively correlated with Cu. The diabetes group's HbA1c and Zn levels were inversely correlated, which suggests that uncontrolled DM causes a reduction in Zn levels. Cu and Mg correlated positively with HbA1c in healthy people but not in people with diabetes.
CONCLUSION: As the enzyme α-amylase correlated with HbA1c and glucose levels, it may serve as a supplementary marker of pancreatic exocrine involvement in patients with diabetes, but its predictive or diagnostic utility remains unproven. The pathophysiology of DM is complicated by altered trace element levels.
CASE DESCRIPTION: Eighteen healthy control subjects and 31 patients with type 2 diabetes from both genders were recruited for this study. The enzymatic colorimetric method was used to assess serum glucose levels and α-amylase activity. The boronate affinity method and atomic absorption spectroscopy were used to measure HbA1c and trace elements, respectively.
DISCUSSION: In comparison to the control group, the diabetes groups' mean levels of α-amylase were slightly higher. The Cu level was significantly increased (P < 0.05) in the patient group, whereas Zn and Mg levels did not change significantly. HbA1c demonstrated a significant negative correlation (r = -0.394, P < 0.05) with α-amylase in patients with diabetes. The α-amylase also exhibited a negative correlation with glucose level in these patients. Cu level increased in hyperglycemia, and α-amylase negatively correlated with Cu. The diabetes group's HbA1c and Zn levels were inversely correlated, which suggests that uncontrolled DM causes a reduction in Zn levels. Cu and Mg correlated positively with HbA1c in healthy people but not in people with diabetes.
CONCLUSION: As the enzyme α-amylase correlated with HbA1c and glucose levels, it may serve as a supplementary marker of pancreatic exocrine involvement in patients with diabetes, but its predictive or diagnostic utility remains unproven. The pathophysiology of DM is complicated by altered trace element levels.