Evaluation of antioxidant enzyme activity among Indian patients with type 2 diabetes mellitus.

Oxidative stress is a key factor in the pathogenesis of Type 2 Diabetes Mellitus (T2DM), and the role of antioxidant enzymes in managing this stress remains an important area of research. Therefore, it is of interest to investigate the activity of antioxidant enzymes (SOD, CAT and GPx) in patients with Type 2 Diabetes Mellitus (T2DM) to understand the relationship between glycemic control and oxidative stress. We found significantly lower enzyme activity in individuals with poor glycemic control (HbA1c ≥ 7%) compared to those with better control (HbA1c < 7%). Negative correlations were observed between antioxidant enzyme levels and clinical variables such as HbA1c and fasting blood glucose. Our findings suggest that antioxidant enzyme activity may play a crucial role in managing oxidative stress in T2DM. Further studies should explore the potential of antioxidant-based therapies. The advancement to knowledge in this study is the identification of reduced antioxidant enzyme activity in patients with poor glycemic control, highlighting its potential role in managing oxidative stress in Type 2 Diabetes Mellitus.