International dental journal · 2026
Dentofacial Malocclusion and Salivary Biomarkers in Asthmatic Patients: A Scoping Review.
СтатьяScoping ReviewНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Raghavan Shailaja, Alhaija Elham S Abu, Almashraqi Abeer A
Аннотация
OBJECTIVE: To explore the association between asthma, dentofacial malocclusion, and salivary biomarkers, providing an understanding of current evidence, identifying gaps in knowledge, and highlighting future research priorities in the field.
METHODS: Joanna Briggs Institute guidance for conducting and PRISMA-ScR reporting were the guidelines followed. Comprehensive searches of PubMed, Scopus, Embase, Google Scholar, and ProQuest identified case-control and cross-sectional studies published between 2000 and August 2025 that assessed asthma in relation to malocclusion or salivary biomarkers.
RESULTS: Twenty-two studies were included: nine on malocclusion and 13 on salivary biomarkers. Most studies reported increased prevalence of posterior crossbite, anterior open bite, and greater palatal depth among asthmatics, while maxillary intermolar/interpremolar width and overbite were reduced. The findings for overjet, Angle's classification, and other dental parameters were variable. Crowding showed no significant association with asthma. Salivary IL-6 and VEGF were higher in asthmatics, whereas IL-8 showed variable results with most of the included studies reporting no change in their levels. Eosinophilic cationic protein was generally elevated, while alpha amylase and IL-1β levels were unchanged. Other salivary biomarkers such as IP-10 and malondialdehyde showed variable findings across the studies.
CONCLUSIONS: A limited evidence suggests asthma to be linked to both dentofacial malocclusion and altered salivary biomarker levels.
METHODS: Joanna Briggs Institute guidance for conducting and PRISMA-ScR reporting were the guidelines followed. Comprehensive searches of PubMed, Scopus, Embase, Google Scholar, and ProQuest identified case-control and cross-sectional studies published between 2000 and August 2025 that assessed asthma in relation to malocclusion or salivary biomarkers.
RESULTS: Twenty-two studies were included: nine on malocclusion and 13 on salivary biomarkers. Most studies reported increased prevalence of posterior crossbite, anterior open bite, and greater palatal depth among asthmatics, while maxillary intermolar/interpremolar width and overbite were reduced. The findings for overjet, Angle's classification, and other dental parameters were variable. Crowding showed no significant association with asthma. Salivary IL-6 and VEGF were higher in asthmatics, whereas IL-8 showed variable results with most of the included studies reporting no change in their levels. Eosinophilic cationic protein was generally elevated, while alpha amylase and IL-1β levels were unchanged. Other salivary biomarkers such as IP-10 and malondialdehyde showed variable findings across the studies.
CONCLUSIONS: A limited evidence suggests asthma to be linked to both dentofacial malocclusion and altered salivary biomarker levels.