Epidemiology (Cambridge, Mass.) · 2007
Anthropometric characteristics and risk of uterine leiomyoma.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Terry Kathryn L, De Vivo Immaculata, Hankinson Susan E, Spiegelman Donna, Wise Lauren A, Missmer Stacey A
Аннотация
BACKGROUND: The etiology of uterine leiomyoma (or fibroids) is poorly understood. Sex steroid hormones and growth factors have been hypothesized to play a role in their development, and anthropometric characteristics may influence uterine leiomyoma risk.
METHODS: We analyzed prospectively-collected data from the Nurses' Health Study II, a cohort of 116,609 female registered nurses age 25 to 42 years at baseline. Incidence of uterine leiomyoma and anthropometric characteristics were assessed every 2 years. We calculated hazard ratios and 95% confidence intervals adjusted for known and suspected risk factors for uterine leiomyoma.
RESULTS: Uterine leiomyomas were associated with current body mass index, change in weight since age 18, and waist-to-hip ratio. However, there was little evidence of their association with body mass index at age 18, childhood or adolescent body size, or adult height.
CONCLUSION: Body mass and weight gain in adulthood may increase the risk of uterine leiomyoma, but body mass in early life does not.
METHODS: We analyzed prospectively-collected data from the Nurses' Health Study II, a cohort of 116,609 female registered nurses age 25 to 42 years at baseline. Incidence of uterine leiomyoma and anthropometric characteristics were assessed every 2 years. We calculated hazard ratios and 95% confidence intervals adjusted for known and suspected risk factors for uterine leiomyoma.
RESULTS: Uterine leiomyomas were associated with current body mass index, change in weight since age 18, and waist-to-hip ratio. However, there was little evidence of their association with body mass index at age 18, childhood or adolescent body size, or adult height.
CONCLUSION: Body mass and weight gain in adulthood may increase the risk of uterine leiomyoma, but body mass in early life does not.