The Laryngoscope · 2012
Management of nonesthesioneuroblastoma sinonasal malignancies with neuroendocrine differentiation.
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Fried David, Zanation Adam M, Huang Benjamin, Hayes Neil, Morris David E, Rosenman Julian, Varia Mahesh, Funkhouser William, Weissler Mark, Chera Bhishamjit S
Аннотация
OBJECTIVES/HYPOTHESIS: Report the outcomes of patients with nonesthesioneuroblastoma (non-ENB) sinonasal malignancies with neuroendocrine differentiation.
STUDY DESIGN: Single Institution Retrospective Case Series.
METHODS: We conducted a retrospective chart review of 19 biopsy-proven non-ENB sinonasal neuroendocrine carcinomas diagnosed between 1997 and 2010 and treated with multimodality therapy. Kaplan-Meier estimates of local-regional control (LRC), distant metastases-free survival (DMFS), and overall survival (OS) were calculated.
RESULTS: The 3-year LRC, FFDM, and OS rates were 63%, 50%, and 64%, respectively. All nine patients receiving neoadjuvant chemoradiotherapy (CRT) had at least a pathologic partial response: three of seven sinonasal undifferentiated carcinomas and two of two sinonasal neuroendocrine carcinomas had complete pathological responses. All five patients with pathologic complete responses were alive without disease at a median follow-up of 43 (29-67) months.
CONCLUSIONS: Having a complete response pathologically to CRT was a favorable prognostic indicator. Neoadjuvant CRT followed by surgery seems to be an efficacious sequence of multimodality therapy.
STUDY DESIGN: Single Institution Retrospective Case Series.
METHODS: We conducted a retrospective chart review of 19 biopsy-proven non-ENB sinonasal neuroendocrine carcinomas diagnosed between 1997 and 2010 and treated with multimodality therapy. Kaplan-Meier estimates of local-regional control (LRC), distant metastases-free survival (DMFS), and overall survival (OS) were calculated.
RESULTS: The 3-year LRC, FFDM, and OS rates were 63%, 50%, and 64%, respectively. All nine patients receiving neoadjuvant chemoradiotherapy (CRT) had at least a pathologic partial response: three of seven sinonasal undifferentiated carcinomas and two of two sinonasal neuroendocrine carcinomas had complete pathological responses. All five patients with pathologic complete responses were alive without disease at a median follow-up of 43 (29-67) months.
CONCLUSIONS: Having a complete response pathologically to CRT was a favorable prognostic indicator. Neoadjuvant CRT followed by surgery seems to be an efficacious sequence of multimodality therapy.
Предметные рубрики MeSH
AdultAntineoplastic Combined Chemotherapy ProtocolsCarcinomaCell DifferentiationCerebrospinal Fluid LeakCerebrospinal Fluid RhinorrheaChemoradiotherapy, AdjuvantDisease-Free SurvivalEndoscopyFemaleFollow-Up StudiesHumansKaplan-Meier EstimateMaleMaxillary Sinus NeoplasmsNeoadjuvant TherapyNeoplasm Recurrence, LocalNeoplasm StagingOsteoradionecrosisRadiographyRetrospective StudiesSurvival RateTreatment Outcome