Emerging infectious diseases · 2020
Candidatus Mycoplasma haemohominis in Human, Japan.
Клинический случайСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Hattori Norimichi, Kuroda Makoto, Katano Harutaka, Takuma Takahiro, Ito Takayoshi, Arai Nana, Yanai Ryo, Sekizuka Tsuyoshi, Ishii Sho, Miura Yoko, Tokunaga Takahiro, Watanabe Hiroyuki, Nomura Norihiro, Eguchi Junichi, Hasegawa Hideki, Nakamaki Tsuyoshi, Wakita Takaji, Niki Yoshihito
Аннотация
Hemotropic mycoplasmas are common pathogens in animals, but it remains unclear what role these pathogens play in human infections. We report clinical and biologic characterization of Candidatus Mycoplasma haemohominis infection in a 42-year-old man in Japan. The patient had severe hemophagocytic syndrome 1 month after an accidental needlestick injury. Metagenomic deep sequencing identified Candidatus M. haemohominis and determined its draft genome for an isolate from serum of the patient. A high copy number of the Candidatus M. haemohominis genome was detected in serum and bone marrow samples. Electron microscopy examination showed morphologic characteristics of Candidatus M. haemohominis. Levofloxacin monotherapy induced resistance caused by a gyrase A gene mutation in the quinolone resistance-determining region, but a combination treatment with moxifloxacin and minocycline was effective. We identified Candidatus M. haemohominis in a patient who had life-threatening symptoms related to multiple organ infection. Human infection with this mycoplasma might occur more frequently than has been generally recognized.