Acute ocular toxicity study of Chandrodaya Varti Anjana in albino rabbits: A safety assessment.

Cataract is a clouding of the lens, that normally affects vision. It is the leading cause of reversible blindness and visual impairment globally. Chandrodaya Varti Anjana, a classical Ayurvedic herbo mineral formulation, is widely used in ophthalmic practice for conditions such as Timira (∼blurred vision), Arma (∼pterygium) and Kacha (∼opacity of lens). Despite its clinical acceptance, toxicological evaluation of its ocular safety is limited. Aim of the study is to evaluate the acute ocular toxicity of Chandrodaya Varti Anjana in albino rabbits. Albino rabbits were included for the study after approval of IAEC. As per the OECD guidelines 0.1 g of testing drug was placed in the conjunctival sac of one eye each animal. The lids were then gently held together for 2 s. Throughout the 21-days study period, none of the test animals exhibited conjunctival corneal, or iridial reactions and no signs of chemosis were observed. Acute ocular toxicity study indicates that topical application of Chandrodaya Varti Anjana was well-tolerated in albino rabbits without any signs of ocular toxicity. These findings provide a preliminary safety profile that supports the potential for future clinical evaluation in humans. However, further studies with larger animal samples and controlled human clinical trials are necessary to establish definitive safety and efficacy.