Journal of global antimicrobial resistance · 2025
Colistin-resistant Klebsiella pneumoniae species complex: The scenario in Mexico.
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Rodríguez-Santiago Jonathan, Alvarado-Delgado Alejandro, Rodríguez-Medina Nadia, Garza-González Elvira, Tellez-Sosa Juan, Duarte-Zambrano Luis, Nava-Domínguez Neli, Sohlenkamp Christian, Vences-Guzmán Miguel A, López-Jácome Luis Esaú, Morfin-Otero Rayo, Rodriguez-Noriega Eduardo, Hernández-Castro Rigoberto, Mireles-Dávalos Christian, Becerril-Vargas Eduardo, Mena-Ramírez Juan Pablo, Cruz-García Edgar, Garza-Ramos Ulises
Аннотация
OBJECTIVE: Characterize the colistin-resistance mechanisms, determine the molecular epidemiology, and genomic traits of the colistin-resistant Klebsiella pneumoniae species complex (ColR-KpSC) clinical isolates in Mexico.
METHODS: In this study, 1539 KpSC isolates were collected in Mexico from 2016 to 2021. We conducted a comprehensive analysis that included microbiological, genetic, molecular, and genomic approaches.
RESULTS: A total of 50 isolates (3.25%) were colistin-resistant; of which 49 (98%) corresponded to K. pneumoniae and 1 (2%) to Klebsiella quasipneumoniae. Whole genome sequencing of these resistant isolates revealed intra- and inter-hospital dissemination, and the mgrB inactivation was the main resistance mechanism. Some KpSC isolates carried plasmid-borne mcr-1 gene found in Escherichia coli from piglets in Mexico. The colistin-resistant isolates presented a high prevalence of extended-spectrum β-lactamases- and NDM-1 genes, and one hypervirulent strain also produced extended-spectrum β-lactamases CTX-M-15.
CONCLUSIONS: This study provides a comprehensive snapshot of the epidemiology of ColR-KpSC in Mexico, highlighting a high prevalence of NDM-1 carbapenemase among ColR-KpSC isolates; this is in line with previous reports identifying NDM-1 as the most prevalent carbapenemase in KpSC. This problem is particularly concerning in Mexico because of the lack of therapeutic options.
METHODS: In this study, 1539 KpSC isolates were collected in Mexico from 2016 to 2021. We conducted a comprehensive analysis that included microbiological, genetic, molecular, and genomic approaches.
RESULTS: A total of 50 isolates (3.25%) were colistin-resistant; of which 49 (98%) corresponded to K. pneumoniae and 1 (2%) to Klebsiella quasipneumoniae. Whole genome sequencing of these resistant isolates revealed intra- and inter-hospital dissemination, and the mgrB inactivation was the main resistance mechanism. Some KpSC isolates carried plasmid-borne mcr-1 gene found in Escherichia coli from piglets in Mexico. The colistin-resistant isolates presented a high prevalence of extended-spectrum β-lactamases- and NDM-1 genes, and one hypervirulent strain also produced extended-spectrum β-lactamases CTX-M-15.
CONCLUSIONS: This study provides a comprehensive snapshot of the epidemiology of ColR-KpSC in Mexico, highlighting a high prevalence of NDM-1 carbapenemase among ColR-KpSC isolates; this is in line with previous reports identifying NDM-1 as the most prevalent carbapenemase in KpSC. This problem is particularly concerning in Mexico because of the lack of therapeutic options.