Digestion · 2009
Effect of irsogladine maleate on NSAID-induced reduction of gastric mucosal blood flow in anesthetized dogs.
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Sato Motonori, Manabe Noriaki, Hata Jiro, Ishii Manabu, Kamada Tomoari, Kusunoki Hiroaki, Shiotani Akiko, Haruma Ken
Аннотация
BACKGROUND AND AIM: Although mucoprotective agents are commonly used against gastric and duodenal lesions in Japan, their availability as agents for non-steroidal anti-inflammatory drug (NSAID)-induced gastrointestinal damage has not been clarified. To investigate the effect of irsogladine maleate (IM) on gastric mucosal blood flow (GMBF) reduction induced by diclofenac sodium, a NSAID commonly used in Japan, by laser Doppler flowmetry (LDF) and ultrasonography (US) in canine stomach.
METHODS: GMBF was measured by LDF and contrast-enhanced US in 15 beagles. US was performed employing real-time harmonic imaging under low acoustic power after intravenous contrast injection using Definity (60 mg/kg). 60 min after insertion of a diclofenac sodium suppository (1.0 mg/kg) into the rectum, LDF and contrast-enhanced US were repeated. The examination was done in a crossover, single-blinded fashion.
RESULTS: The mean extent of the change in GMBF in the IM group and in the placebo group was +29.3 and -38%, respectively.
CONCLUSIONS: IM alleviates the reduction of GMBF induced by diclofenac sodium.
METHODS: GMBF was measured by LDF and contrast-enhanced US in 15 beagles. US was performed employing real-time harmonic imaging under low acoustic power after intravenous contrast injection using Definity (60 mg/kg). 60 min after insertion of a diclofenac sodium suppository (1.0 mg/kg) into the rectum, LDF and contrast-enhanced US were repeated. The examination was done in a crossover, single-blinded fashion.
RESULTS: The mean extent of the change in GMBF in the IM group and in the placebo group was +29.3 and -38%, respectively.
CONCLUSIONS: IM alleviates the reduction of GMBF induced by diclofenac sodium.