Annals of clinical and translational neurology · 2026
Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wang Yingtao, Tao Shaoxin, Wang Qiujia, Xu Xiaoyu, Yao Hui, Liu Zheng, Li Dawei, Qiu Zhandong, Han Jinming, Xia Jiangwei, Wang Qi, Sun Jun, Shao Kai, Li Jiao, Ruan Shishuang, Zhong Yi, Guo Jun, Guo Shougang, Huang Yue, Chai Guoliang, Jin Tao, Zhou Hongyu, Hao Junwei, Zhao Yinan
Аннотация
BACKGROUND: Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) remain incompletely understood.
OBJECTIVES: To identify clinical and modifiable factors associated with relapse and disability in MOGAD.
METHODS: In this ambispective multicentre cohort study using data from the Chinese Neuroimmunological Diseases (NIDBase) cohort (21 Chinese centres; January 2020-December 2024), 173 MOGAD patients with ≥ 12-month follow-up were analysed. Time to first relapse and time to disability, defined as Expanded Disability Status Scale (EDSS) score ≥ 2 confirmed outside acute relapse periods, were analysed using Cox regression. Nonlinear associations were assessed using restricted cubic splines.
RESULTS: Older age at onset and smoking history were associated with increased disability risk. Smoking was also associated with relapse risk, although its association was attenuated and no longer statistically significant after adjustment. BMI showed nonlinear associations with both relapse and disability outcomes.
CONCLUSIONS: In MOGAD, older age at onset, smoking, and BMI may influence prognosis. These findings support further investigation of modifiable lifestyle and metabolic factors in prognostic stratification.
OBJECTIVES: To identify clinical and modifiable factors associated with relapse and disability in MOGAD.
METHODS: In this ambispective multicentre cohort study using data from the Chinese Neuroimmunological Diseases (NIDBase) cohort (21 Chinese centres; January 2020-December 2024), 173 MOGAD patients with ≥ 12-month follow-up were analysed. Time to first relapse and time to disability, defined as Expanded Disability Status Scale (EDSS) score ≥ 2 confirmed outside acute relapse periods, were analysed using Cox regression. Nonlinear associations were assessed using restricted cubic splines.
RESULTS: Older age at onset and smoking history were associated with increased disability risk. Smoking was also associated with relapse risk, although its association was attenuated and no longer statistically significant after adjustment. BMI showed nonlinear associations with both relapse and disability outcomes.
CONCLUSIONS: In MOGAD, older age at onset, smoking, and BMI may influence prognosis. These findings support further investigation of modifiable lifestyle and metabolic factors in prognostic stratification.