Pigment cell & melanoma research · 2011
Koebner's phenomenon in vitiligo: European position paper.
СтатьяОбзорНазвание и аннотация: Перевод пока не подготовлен
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van Geel Nanja, Speeckaert Reinhart, Taieb Alain, Picardo Mauro, Böhm Markus, Gawkrodger David J, Schallreuter Karin, Bennett Dorothy C, van der Veen Wietze, Whitton Maxine, Moretti Silvia, Westerhof Wiete, Ezzedine Khaled, Gauthier Yvon, VETF members
Аннотация
Koebner's phenomenon (KP) has been observed in a number of skin diseases, including vitiligo. Its clinical significance in vitiligo with respect to disease activity and course is still debatable, while its relevance for surgical techniques has been demonstrated in some reports. We present a literature review on the currently known facts about KP in vitiligo, including details of clinical, experimental, and histopathological changes. The consensus view is that there are still no methods to define and assess KP in vitiligo. A new classification is proposed to allow an evaluation of KP in daily practice or in experimental studies. However, many unanswered questions still remain after redefining KP in patients with vitiligo. Active research focusing on KP in vitiligo may not only provide unexpected clues in the pathogenesis of vitiligo but also help to tailor novel therapies against this chronic and often psychologically devastating skin disease.