The suppression of sheep rosette-forming cells and the inability of mouse bone marrow cells to reconstitute competence after infbction with the nematode Trichinella spiralis.

Mice infected with the nematode Trichinella spiralis or normal mice treated either with the serum of infected animals or with a parasite extract contained fewer spleen rosette-forming cells (RFC) to sheep erythrocytes than the controls. Bone marrow cells from infected mice were considerably less efficient than normal cells in reconstituting thymectomized, irradiated animals.