The impact of smoking on postoperative complications following elective off-pump CABG in an ERAS setting.

PURPOSE: This study investigates the impact of smoking on major postoperative complications following elective off-pump coronary artery bypass graft (CABG) surgery within an enhanced recovery after surgery (ERAS) program.

METHODS

A total of 3168 patients who underwent elective off-pump and minimally invasive direct CABG under ERAS between January 1, 2017, and December 31, 2020, were enrolled. Propensity score matching was applied to minimize potential confounders when comparing postoperative outcomes between smokers and non-smokers.

RESULTS

Multivariate logistic regression analyses showed no significant difference in 30-day postoperative mortality between smokers and non-smokers (adjusted odds ratio [aOR]: 1.06, 95% confidence interval [CI]: 0.40-1.56). However, smokers had a higher risk of 30-day major complications, including postoperative acute myocardial infarction (AMI) (aOR: 1.43, 95% CI: 1.02-1.99) and overall postoperative complications (aOR: 1.18, 95% CI: 1.04-1.48). Similarly, for the 31-90-day period, smokers had no significantly higher risk of mortality (aOR: 1.06, 95% CI: 0.49-1.19), but experienced higher rates of major complications, including postoperative AMI (aOR: 1.73, 95% CI: 1.17-2.55) and overall postoperative complications (aOR: 1.48, 95% CI: 1.13-1.92).

CONCLUSIONS

The ERAS program benefits patients undergoing CABG surgery, including smokers, by providing similar major postoperative outcomes to non-smokers, except for increased risks of postoperative AMI and overall complications.