Short-Term Efficacy of Autologous Cellular Micrografts in Male and Female Androgenetic Alopecia: A Retrospective Cohort Study.

PURPOSE: Autologous cellular micrografts (ACM) is a novel treatment method in hair loss, and few data are available regarding its efficacy. The present study was carried out to assess the short-term clinical efficacy of a single application of ACM in the treatment of male and female androgenetic alopecia (AGA).

MATERIALS AND

METHODS

This was a single-center retrospective study involving 140 consecutive adults with confirmed AGA, who received a single session of ACM (Regenera Activa®). Efficacy was evaluated 1-6 months after treatment, by analyzing the change of trichometry parameters, which were assessed using TrichoScan digital image analysis.

RESULTS

Depending on the scalp region, there was increase in mean hair density by 4.5-7.12 hair/cm2, average hair thickness by 0.96-1.88 μm, % thick hair by 1.74-3.26%, and mean number of follicular units by 1.30-2.77, resulting in an increase of cumulative hair thickness by 0.48-0.56 unit. Additionally, the frontal region showed a significant decrease in % thin hair (-1.81%, p = 0.037) and yellow dots (-1.93 N/cm2, p = 0.003). A favorable response was observed in 66.4% of the participants in the frontal region. Further, a gender-specific effect of treatment was observed.

CONCLUSION

ACM is a promising treatment in AGA with a short-term favorable response observed in up to approximately two-thirds of patients.