Molecular insights into Pterygium: The emerging role of microRNAs in pathogenesis and therapeutic potential.

PURPOSE: Pterygium is a common ocular surface disorder, particularly prevalent in tropical regions, that can lead to visual impairment and ocular discomfort. Understanding the molecular mechanisms involved in Pterygium formation is crucial for improving outcomes and reducing recurrence. The objective of this study was to elucidate the key microRNAs (miRNAs) and molecular pathways involved in the pathogenesis of Pterygium.

METHODS

This study investigates the molecular mechanisms underlying the disease and the function of microRNAs in its onset, progression, and therapy by analyzing credible scientific databases and the associated literature.

RESULTS

Several miRNAs (such as the miR-200 family) have been associated with the development and clinical severity of Pterygium through mechanisms involving cell proliferation, apoptosis, IL-17 signaling, insulin-like growth factor binding protein-2 (IGFBP-2), and epithelial-mesenchymal transition (EMT).

CONCLUSIONS

understanding the molecular pathways associated with Pterygium may facilitate the identification of potential preventive strategies and therapeutic targets, although further validation is required before clinical application.