Archives of oral biology · 2025
Developmental defects of enamel in preschool twins - Coincidences, heritability, and multilevel analysis.
СтатьяTwin StudyНазвание и аннотация: Перевод в очереди
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Matias-Santos Francisca Aline da Silva, Lopes Letícia Caminha Aguiar, Sousa Maria Eduarda Matos, Nascimento Viviane Oliveira do, Moura Marcoeli Silva de, Lima Cacilda Castelo Branco, Mendes Fausto Medeiros, Moura Lúcia de Fátima Almeida de Deus, Lima Marina de Deus Moura de
Аннотация
OBJECTIVE: To compare the coincidences of developmental defects of enamel (DDE) between monozygotic and dizygotic twins, determine heritability in primary dentition, and identify associated factors.
DESIGN: A cross-sectional study was conducted among preschool twins aged 3-5 years in Teresina, Brazil. Non-cooperative children were excluded. Data were collected through questionnaires and clinical examinations. Clinical assessment was conducted in a school setting using the modified DDE Index for diagnostic purposes. Coincidences were analyzed using tetrachoric correlations and multinomial logistic regression, deriving Odds Ratios (OR) and 95 % confidence intervals (95 %CI). Heritability was estimated using Holzinger's formula. Multilevel Poisson regression identified associated factors with developmental defects of enamel occurrence (p < 0.05).
RESULTS: In total, 239 twin pairs were included (Monozygotic = 96, Dizygotic = 143). Correlations for developmental defects of enamel were strong/very strong in monozygotic (overall DDE, 0.829; demarcated opacities, 0.645; diffuse opacities, 0.812; hypoplasia, 0.786) and weak/moderate in dizygotic (overall DDE, 0.322; demarcated opacities, 0.076; diffuse opacities, 0.562; hypoplasia, 0.156). Monozygotic twins had more positive (OR; 95 %CI = 2.04; 1.01-4.08) and negative coincidences (OR; 95 %CI = 3.91; 1.47-10.36) than dizygotic twins did. Heritability was 74.8 %. Pre-eclampsia/eclampsia and high fever during the first year of life were associated with a higher prevalence of DDE in primary dentition.
CONCLUSIONS: Higher coincidences in monozygotic twins and high heritability suggest a genetic influence on the development of developmental defects of enamel in primary dentition. Pre-eclampsia/eclampsia and high fever in the first year of life were associated factors.
DESIGN: A cross-sectional study was conducted among preschool twins aged 3-5 years in Teresina, Brazil. Non-cooperative children were excluded. Data were collected through questionnaires and clinical examinations. Clinical assessment was conducted in a school setting using the modified DDE Index for diagnostic purposes. Coincidences were analyzed using tetrachoric correlations and multinomial logistic regression, deriving Odds Ratios (OR) and 95 % confidence intervals (95 %CI). Heritability was estimated using Holzinger's formula. Multilevel Poisson regression identified associated factors with developmental defects of enamel occurrence (p < 0.05).
RESULTS: In total, 239 twin pairs were included (Monozygotic = 96, Dizygotic = 143). Correlations for developmental defects of enamel were strong/very strong in monozygotic (overall DDE, 0.829; demarcated opacities, 0.645; diffuse opacities, 0.812; hypoplasia, 0.786) and weak/moderate in dizygotic (overall DDE, 0.322; demarcated opacities, 0.076; diffuse opacities, 0.562; hypoplasia, 0.156). Monozygotic twins had more positive (OR; 95 %CI = 2.04; 1.01-4.08) and negative coincidences (OR; 95 %CI = 3.91; 1.47-10.36) than dizygotic twins did. Heritability was 74.8 %. Pre-eclampsia/eclampsia and high fever during the first year of life were associated with a higher prevalence of DDE in primary dentition.
CONCLUSIONS: Higher coincidences in monozygotic twins and high heritability suggest a genetic influence on the development of developmental defects of enamel in primary dentition. Pre-eclampsia/eclampsia and high fever in the first year of life were associated factors.