Chinese expert consensus on conversion and perioperative therapy of primary liver cancer (2024 edition).
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wang Zheng, Sun Huichuan, Zhou Jian, Xie Qing, Bi Xinyu, Liu Xiufeng, Liu Rong, Zhao Ming, Bai Xueli, Ji Yuan, Xu Li, Jia Weidong, Zeng Shaochong, Li Gong, Zhang Wei, Shen Shunli, Rao Shengxiang, Shi Guoming, Zhang Lan, Zhu Xiaodong, Wu Zhifeng, Wang Jiabei, Tang Haowen, Bai Dousheng, Chen Yajin, Chen Yongjun, Dai Chaoliu, Gu Fangming, Guo Jinhe, Guo Rongping, Guo Wenzhi, Han Feng, Han Guohong, Hao Chunyi, Huang Tao, Huang Xiaolun, Huang Yangqing, Huang Zhiyong, Jiao Shunchang, Li Deyu, Li Tao, Li Xiangcheng, Li Guangming, Liang Ping, Liang Xiao, Lin Jinguan, Liu Fubao, Liu Jiwei, Liu Jingfeng, Lu Zheng, Lv Weifu, Mao Yilei, Meng Zhiqiang, Peng Chuang, Peng Li, Peng Tao, Shi Ming, Shi Yinghong, Song Tianqiang, Tan Guang, Tang Yunqiang, Tao Kaishan, Wan Chidan, Wang Guangyi, Wang Kui, Wang Lu, Wang Maoqiang, Wang Shunxiang, Wang Wentao, Wen Tianfu, Xiang Bangde, Xing Baocai, Xu Jianming, Xu Jun, Yan Sheng, Yang Dinghua, Yang Jiayin, Yin Guowen, Yu Zhengping, Zeng Yongyi, Zhang Jialin, Zhang Shuijun, Zhang Ti, Zhang Yamin, Zhang Yu, Zhang Yubao, Zhang Zhiwei, Zhang Aibin, Zhao Haitao, Zhao Hong, Zhou Ledu, Zhou Weiping, Zhu Zhenyu, Qin Shukui, Shen Feng, Cai Xiujun, Cai Jianqiang, Chen Minshan, Li Qiang, Liu Lianxin, Wang Weilin, Liang Tingbo, Zhang Bixiang, Lu Shichun, Cheng Shuqun, Ren Zhenggang, Wu Hong, Kuang Ming, Teng Gaojun, Dou Kefeng, Dong Jiahong, Chen Xiaoping, Wang Xuehao, Zheng Shusen, Fan Jia, Alliance of Liver Cancer Conversion Therapy, Liver Cancer Committee, China Anti-Cancer Association
Аннотация
METHODS: A multidisciplinary committee of 97 experts was convened to revise previous guidelines. The process involved a comprehensive search of medical databases and conference proceedings, with evidence graded according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. Consensus statements were finalized through a formal electronic voting process, requiring at least 80% agreement for approval, resulting in 18 updated statements.
RESULTS: The consensus provides refined definitions for conversion and perioperative therapy. It recommends various strategies for oncological conversion, including systemic therapy with anti-angiogenic drugs plus immunotherapy, and locoregional approaches like precision transarterial chemoembolization (TACE) and hepatic artery infusion chemotherapy (HAIC). The document strongly affirms surgical resection as a crucial step for achieving long-term survival after successful conversion and offers guidance on surgical timing and adjuvant therapy. For resectable patients with high-risk features, neoadjuvant and adjuvant treatments are outlined to mitigate recurrence. The consensus also advocates for using dynamic enhanced magnetic resonance imaging (MRI) and the modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria for efficacy assessment and underscores the essential role of a multidisciplinary team in management.
CONCLUSIONS: This updated consensus offers standardized, evidence-based guidance for clinicians on implementing conversion and perioperative strategies to optimize patient-centered care and highlights the need for continued research to further refine these promising approaches.