[Biological mechanisms of tibial transverse transport for promoting microcirculation and tissue repair].

OBJECTIVE

To explore the biological mechanisms of tibial transverse transport (TTT) for promoting microcirculation and tissue repair.

METHODS

The clinical application and animal model study of TTT were reviewed.

RESULTS

The possible biological mechanisms of TTT for promoting microvascular network formation and tissue repair: ① Tibial corticotomy reduces intramedullary pressure and improves microcirculation; ② Tension stress stimulation promotes microvascular regeneration and accelerates the formation of new "transcortical vessels" network; ③ Systemic mobilization of stem cells, mediating local inflammation, etc.

CONCLUSION

TTT has been clinically proven to be effective for the management of lower limb ischemia and diabetic foot ulcers. The surgical procedure is relatively easy with little adverse effects on bone structures. The TTT has good application prospects despite the biological mechanisms of which still need further exploration.