Primary Central Nervous System (CNS) Post-Transplant Lymphoproliferative Disorder: A Case Report.

Post-transplant lymphoproliferative disorder (PTLD) is the most common non-dermatologic malignancy in patients with a history of solid organ transplantation (SOT). The onset of PTLD is not limited to a specific timeframe post-SOT, but most cases are diagnosed within five years of transplantation. While both metastatic spread and multifocal involvement are common, very few of these cases arise from the central nervous system. Here, we present a patient with progressive memory loss 15 years after renal transplantation who was found to have primary central nervous system PTLD. This case underscores the importance of continued vigilance in post-transplantation care.