Frontiers in endocrinology · 2026
Effects of polycystic ovary syndrome on liver, heart, muscle, and pancreatic-related diseases.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Li Bingrui, Li Yuan, Li Xianglin, Yu Zicheng, Yu Jin, Shao Yang, Li Tonglu, Sun Shuai, Zhou Ling, Yao Ruipin, Cheng Wen, Zhu Jing, Miao Jindong, Li You, Wu Yang, Shi Yin, Zhou Jing, Yu Chaoqin, Ling Changquan
Аннотация
BACKGROUND: PCOS is far more than an ovarian disorder; it is a systemic metabolic crisis affecting 11-13% of women. This review maps its extra-ovarian reach into the liver, heart, muscle, and pancreas.
METHODS: We analyzed how the "pathophysiological quartet"-insulin resistance, hyperandrogenism, inflammation, and oxidative stress-coordinates systemic damage.
RESULTS: PCOS prevalence skyrockets to 28.3% in women with obesity. Key findings include a 51.61% prevalence of MASLD in obese patients and a 2-4 fold increase in cardiovascular and type 2 diabetes risk. These manifestations are rooted in a shared metabolic "soil," creating a vicious cycle of androgen excess and multi-organ dysfunction, including sarcopenia and β-cell exhaustion.
CONCLUSION: Fragmented care is insufficient. The systemic nature of PCOS demands a paradigm shift toward integrated, multidisciplinary management, treating the patient as a metabolic whole.
METHODS: We analyzed how the "pathophysiological quartet"-insulin resistance, hyperandrogenism, inflammation, and oxidative stress-coordinates systemic damage.
RESULTS: PCOS prevalence skyrockets to 28.3% in women with obesity. Key findings include a 51.61% prevalence of MASLD in obese patients and a 2-4 fold increase in cardiovascular and type 2 diabetes risk. These manifestations are rooted in a shared metabolic "soil," creating a vicious cycle of androgen excess and multi-organ dysfunction, including sarcopenia and β-cell exhaustion.
CONCLUSION: Fragmented care is insufficient. The systemic nature of PCOS demands a paradigm shift toward integrated, multidisciplinary management, treating the patient as a metabolic whole.