The role of the PLR-NLR combination in the prediction of the presence of Helicobacter pylori and its associated complications.

BACKGROUND/AIM: The aim of this study was to investigate the role of the platelet-to-lymphocyte ratio (PLR)-neutrophil-to-lymphocyte ratio (NLR) combination, in the prediction of the presence of Helicobacter pylori (HP) and its associated complications in the gastrointestinal system.

PATIENTS AND

METHODS

In all, 1289 patients who underwent esophagogastroduodenoscopy and biopsy for HP were included in the study.

RESULTS

The ratio of patients with moderate and severe chronic gastritis was higher in HP (+) group than HP (-) group. The ratio of patients with levels 1-3 atrophy and intestinal metaplasia was higher in HP (+) group. Compared with HP (-) group, HP (+) had higher PLR and NLR levels. The ratio of HP (+) patients was higher in high-risk group compared with low- and medium-risk groups. HP invasion stage, the intestinal metaplasia level, and the ratio of patients with atrophy level "3" were higher in high-risk group compared with low- and medium-risk groups. Regression analysis showed that the PLR-NLR combination was an independent risk factor for both HP presence and moderate and severe chronic gastritis.

CONCLUSION

We found the PLR-NLR combination to be a good predictor of HP presence and gastrointestinal complications associated with HP.