Follicle-stimulating hormone receptor autoantibody associated primary ovarian insufficiency successfully treated with corticosteroids: a case report.

OBJECTIVE

To report a case of successful controlled ovarian stimulation (COH) for oocyte cryopreservation in a patient with autoimmune primary ovarian insufficiency (POI) and polyglandular autoimmune syndrome (PGAS) type 2.

DESIGN

Case report.

SETTING

Private in vitro fertilization clinic.

PATIENTS: 25-Year-old woman, G0, with autoimmune POI and PGAS type 2.

INTERVENTIONS: Diagnosis of autoimmune interference with FSH signaling, with subsequent high-dose corticosteroid immune suppression and successful oocyte cryopreservation.

MAIN OUTCOMES MEASURES: Successful stimulation with exogenous gonadotropins, oocyte retrieval, and cryopreservation.

RESULTS

Retrieval and cryopreservation of 36 metaphase-II (MII) oocytes.

CONCLUSIONS

Scrutiny of POI cases will facilitate identification of a subset of patients in whom immune suppression with short-term, high-dose corticosteroids may enable successful COH.